Drug Name

Celebrex (Celecoxib)

Drug Uses

Celecoxib is old for the relief of pain, fever, tumescence, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib does not obstruct the progression of either prototype of arthritis. It reduces no greater than the symptoms and signs of arthritis. Celecoxib has been approved for patients with familial FAP who press not had their colons removed. Celebrex also is approved for the remedy of acute pain and the ache of menstrual cramps (main dysmenorrhea).

How to use

The lowest crap dose should be second-hand for each patient. For the guidance of osteoarthritis, the dose regularly is 100 mg twice quotidian or 200 mg as a single dispense. For rheumatoid arthritis, the portion usually is 100 or 200 mg twice routine. For acute pain or menstrual cramps, the dispense is 400 mg as a single quantity on the first day, followed by an additional 200 mg if needed, then 200mg twice daily as needed. For FAP, the recommended dispense is 400 mg twice diurnal.

Drug Class and Mechanism

Celecoxib is a nonsteroidal anti-explosive drug (NSAID) that is toughened to treat arthritis, pain, menstrual cramps, and colonic polyps. Prostaglandins are chemicals that are influential contributors to the inflammation of arthritis that causes the distress, fever, swelling and tenderness. Celecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase 2), resulting in turn down concentrations of prostaglandins. As a consequence, irritation and its accompanying pain, fever, excrescence and tenderness are reduced. Celecoxib differs from other NSAIDs in that it causes less infection and ulceration of the stomach and intestine (at least with prove inadequate-term treatment) and does not inhibit with the clotting of blood. NSAIDs own been found to block the formation and reduce the expanse of polyps in patients with the genetic condition, familial adenomatous polyposis (FAP). In FAP, patients commence large numbers of polyps in their colons, and the polyps invariably fit malignant. The only remedy of FA

Missed Dose

Conclude the missed dose as directly as you remember. If it is almost pass� for the next dose, overlook the dose you missed and brook only the next regularly scheduled portion as directed. Do not take a doppelgaenger dose of this medication unless your doctor directs way.

Storage

Capsules should be stored at 25 degrees C (77 degrees F). It is okay for blunt periods in temperatures between 15-30 degrees C (59-86 degrees F).

Warnings/Precautions

There are no restrictions on eats, beverages, or activity while alluring celecoxib unless else directed by your doctor. Concomitant use of celecoxib with aspirin or other NSAIDs (e.g., ibuprofen, naproxen, etc.) may multiplication the occurrence of stomach and intestinal ulcers. Fluconazole (Diflucan) increases the concentration of celecoxib in the hull by inhibiting the breakdown of celecoxib in the liver. Accordingly, treatment with celecoxib should be initiated at the lowest recommended doses in patients who are enchanting fluconazole. Celecoxib increases the concentration of lithium (Eskalith) in the blood by 17%. Wherefore, lithium therapy should be closely monitored during and after group therapy with celecoxib. Persons, delightful the anticoagulant (blood thinner) warfarin (Coumadin), should suffer with their blood tested when initiating or changing celecoxib treatment, markedly in the first few days, for any changes in the effects of the anticoagulant. Persons, who liquid more than 3 alcoholic bevera

Possible Side Effects

Although paunch and intestinal ulcers take place with the use of celecoxib, their quantity is less than with other NSAIDs in discourteous-term studies. Celecoxib does not kibitz with the function of the blood platelets and, as a come to pass, does not reduce clotting and advantage to increased bleeding like other NSAIDs. The most proletarian adverse effects are cephalalgia, abdominal pain, dyspepsia, diarrhea, nausea, flatulence and insomnia. Other side effects list fainting, kidney non-starter, heart failure, aggravation of hypertension, thorax ' pain, ringing in the ears, deafness, reconcile oneself to and intestinal ulcers, bleeding, blurred foresight, anxiety, photosensitivity, rig gain, water retention, flu-like symptoms, drowsiness and appreciation. Allergic reactions can come to with celecoxib. Individuals who obtain developed allergic reactions (ill-advised, itching, difficulty breathing) from sulfonamides (e.g., Bactrim), aspirin or other NSAIDs may judgement an allergic reaction to celecoxib and should not swallow celecoxib.

More Information

Warn your doctor in a minute if you develop abdominal suffering, tenderness, or discomfort; nausea; bloody spew out; bloody, black, or hang back stools; unexplained moment gain; swelling or excessively retention; fatigue or dullness; a skin rash; itching; yellowing of the pellicle or eyes;\\"flu-like\\" symptoms; or queer bruising or bleeding. These symptoms could be old signs of dangerous side effects. If you be familiar with any of the following serious side effects, stage taking celecoxib and pursue medical treatment or address your doctor unhesitatingly: an allergic reaction (strain breathing; closing of your throat; enlargement of your lips, boob facetiously, or face; or hives). Other, less precarious side effects may be more credible to occur. Continue to take hold celecoxib and talk to your doctor if you knowledge flatulence or diarrhea; dizziness; nuisance; or insomnia. Side effects, other than those listed here, may also materialize. Talk to your doctor nearby any side effect that seems unique or that is especially bothersome.